Nanofibrous Patch Technology
How it’s Made
Our Nanofibrous Patches are made from carefully selected biodegradable polymers. The polymers are mixed with the drug and then transformed into very small nano fibres using an innovative technology called electro-spinning. The nanofibres are produced by applying electrostatic field between the polymeric solution deposited on a wire. The electrostatic force “spins” the fibers which are then collected in the form of a non-woven mat on a substrate. The structure of the mat is open, reminding of fairy floss. The machine produces rolls of this nano-fibrous mat that are then sent to our manufacturing partner in Europe who transforms them into patches.
How it Works
When the nanofibrous mat comes in contact with moisture, it rapidly dissolves. This rapid dissolution in the presence of a small amount of moisture is due to the magic combination of high surface area provided by the nanofibres and the nature of the polymer. As it dissolves, the patch transfers the drug to the skin where it permeate in a controlled fashion delivering the expected therapeutic effect.
Once the patch is removed after the prescribed application time (from 12h to 72h), in contrast to most commercial patches, no residue remains on the patch and it can be safely disposed in the bin.
Advantages
The encapsulation of the drug in the nanofibres preserves it in an amorphous state which enhances its solubility and bioavailability.
The rapid dissolution of the nanofibres leads to a rapid release of the drug and permeation through the skin.
The permeation of the drug through the skin is enhanced without using permeation enhancers.
This leads to a significantly higher efficiency compared to commercial patches. This means that we can use less drug for the same therapeutic results, ultimately leading to the production of cheaper and smaller patches.
The electro-spinning process is scalable to large industrial scale.